期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 40, 期 3, 页码 130-140出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.01.004
关键词
cancer metabolism; tumor metabolism; cell proliferation; nutrient availability
资金
- Burroughs Wellcome Fund
- Lustgarten Foundation
- American Association for Cancer Research
- National Cancer Institute
- [F30 CA183474]
To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of whole tumors and suggest that additional complexity exists beyond nutrient availability alone in vivo. Whole-body metabolism and tumor heterogeneity also influence the metabolism of tumor cells, and successful targeting of metabolism for cancer therapy will require an understanding of tumor metabolism in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据