期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 38, 期 8, 页码 1443-1448出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0490-6
关键词
Trichosanthes kirilowii; Cucurbitaceae; Trichobenzolignan; Cytotoxic activity
资金
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2011.23]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2011-0025129]
- National Research Foundation of Korea [2011-0025129] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-beta-D-glucopyranoside (5), chrysoeriol-7- O-beta-D-glucopyranoside (6), 10 alpha-cucurbita-5,24-dien-3 beta-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 A mu M, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 A mu M.
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