期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 38, 期 7, 页码 1304-1311出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-015-0585-8
关键词
Houttuynia cordata; Flavonoid; Quercitrin; Lung inflammation; Cytokine
资金
- Korea Food and Drug Administration [12172KFDA989]
- BK21-plus from the Ministry of Education (Korea)
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders.
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