期刊
PEDIATRIC NEPHROLOGY
卷 30, 期 4, 页码 577-587出版社
SPRINGER
DOI: 10.1007/s00467-014-2868-6
关键词
HLA antibodies; Sensitisation; Red blood cell transfusion; Renal transplantation; Transplant waiting times
资金
- National Institute of Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust
- King's College London
Human leukocyte antigen (HLA) sensitisation occurs after transfusion of blood products and transplantation. It can also happen spontaneously through cross-sensitisation from infection and pro-inflammatory events. Patients who are highly sensitised face longer waiting times on organ allocation programmes, more graft rejection and therefore more side effects of immunosuppression, and poorer graft outcomes. In this review, we discuss these issues, along with the limitations of modern HLA detection methods, and potential ways of decreasing HLA antibody development. We do not discuss the removal of antibodies after they have developed.
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