期刊
PEDIATRIC NEPHROLOGY
卷 28, 期 11, 页码 2079-2088出版社
SPRINGER
DOI: 10.1007/s00467-012-2376-5
关键词
Steroid-resistant nephrotic syndrome; Mouse; Zebrafish; Knock-out; Knock-in
资金
- E-Rare (PodoNet)
- EU Commission (EURenOmics)
Animal models of proteinuria and nephrotic syndrome are essential tools for studying the mechanisms of action of abnormalities in individual components of the podocyte and glomerular basement membrane. In recent years a variety of in vivo models have been developed to elucidate the function of specific podocyte proteins and their role in the pathogenesis of proteinuria and glomerulosclerosis. In this overview of the animal models currently available we discuss their contribution to our mechanistic understanding and their potential use in screening for novel targeted therapies of steroid-resistant nephrotic syndrome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据