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Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO

期刊

PEDIATRIC NEPHROLOGY
卷 28, 期 3, 页码 409-414

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SPRINGER
DOI: 10.1007/s00467-012-2304-8

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Clinical practice guidelines; Steroid-resistant nephrotic syndrome; Children; Management

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Kidney Disease: Improving Global Outcomes (KDIGO) recently published the clinical practice guideline on glomerulonephritis (GN) to assist the practitioner caring for patients with GN. Chapter 4 of the guideline focuses on managing children aged 1-18 years with steroid-resistant nephrotic syndrome (SRNS), defined by an inability to achieve complete remission with corticosteroid therapy. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides both the guideline recommendations and a brief review of relevant treatment trials related to each recommendation. This pr,cis serves as a summary of the complete guidelines recently published.

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