期刊
PEDIATRIC NEPHROLOGY
卷 23, 期 3, 页码 403-412出版社
SPRINGER
DOI: 10.1007/s00467-007-0685-x
关键词
NGAL; biomarker; systemic lupus erythematosus (SLE); pediatric SLE (pSLE); lupus nephritis; Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
资金
- NCATS NIH HHS [UL1 TR000077] Funding Source: Medline
- NIAMS NIH HHS [T32 AR007594, AR047363, P60 AR47784] Funding Source: Medline
- NIDDK NIH HHS [P50 DK52612, R01 DK53289, R21 DK060163] Funding Source: Medline
We hypothesized that neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of disease activity in lupus nephritis. NGAL in serial plasma (PNGAL) and urine (UNGAL) samples was measured by enzyme-linked immunosorbent assay (ELISA) in 85 participants with pediatric systemic lupus erythematosus (pSLE), healthy children (n=50), and children with juvenile idiopathic arthritis (JIA) (n=30). Disease activity was measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Plasma and urinary NGAL were significantly increased in subjects with pSLE compared with those with JIA or with healthy controls (all p < 0.03), and unrelated to subjects' age, weight, or height. Plasma and urinary NGAL were stable in pSLE subjects with unchanged disease activity. The pSLE subjects with worsening global or renal disease activity had a mean +/- standard error (SE) increase of UNGAL (in ng/ml) of 11.5 +/- 6.4 or 36.6 +/- 12.1 (p < 0.01), corresponding to a 156% or 380% increase, respectively. PNGAL increased with worsening disease but to a much lesser degree than UNGAL [global disease activity (mean +/- SE): 7.3 +/- 6.2 or 21%; renal disease activity: 20.2 +/- 6.0 or 51%; both p=not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE.
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