期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 32, 期 10, 页码 1055-1060出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e31829be0b0
关键词
acute otitis media; complicated acute otitis media; otitis media with effusion; recurrent acute otitis media; vitamin D; vitamin D supplementation
资金
- Italian Ministry of Health to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico [2012 850/02]
Background: The aim of this study was to evaluate whether a deficit in vitamin D (VD) is associated with an increased risk of recurrent acute otitis media (AOM) and whether VD supplementation is effective in reducing the number of AOM episodes in otitis-prone children. Methods: A total of 116 children with a history of recurrent AOM (3 episodes in preceding 6 months or 4 episodes in preceding 12 months) were prospectively and blindly randomized to receive oral VD 1000 IU/d or placebo for 4 months. Episodes of AOM were monitored for 6 months. Results: Fifty-eight children received placebo and 58 with similar characteristics were treated with VD. The number of children experiencing 1 AOM episode during the study period was significantly lower in the treatment group (26 versus 38; P = 0.03). There was a marked difference in the number of children who developed uncomplicated AOM (P < 0.001), but no difference in the number of children with 1 episode of spontaneous otorrhea. The likelihood of AOM was significantly reduced in the patients whose serum VD concentrations were 30ng/mL. Conclusions: VD hypovitaminosis is common in children with recurrent AOM and associated with an increase in the occurrence of AOM when serum 25(OH)D levels are <30ng/mL. The administration of VD in a dosage of 1000 IU/d restores serum values of 30ng/mL in most cases and is associated with a significant reduction in the risk of uncomplicated AOM.
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