期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 32, 期 5, 页码 431-435出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e318281e34f
关键词
breast-feeding; respiratory illness; infants
资金
- Bill and Melinda Gates Foundation
- United States Agency for International Development [HRN-A-0096-90006-00]
- Wyeth Pharmaceuticals Inc (Madison, NJ)
- Thrasher Research Fund
- Aventis Pasteur (Swiftwater, PA)
- ICDDR,B
- Bloomberg School of Public Health at Johns Hopkins University (Baltimore, MD)
- Department of Health and Human Services
- National Institutes of Health
- National Eye Institute Training Grant Clinical Trials Training Program in Vision Research [EY 07127]
Background: Exclusive breast-feeding reduces the risk of respiratory illness in infants younger than 6 months of age in developing countries by approximately half. We evaluated the effect of exclusive breast-feeding on respiratory illness with fever (RIF) in Bangladeshi infants in the context of a randomized maternal influenza immunization trial. Methods: Infants in a maternal vaccine trial in Dhaka, Bangladesh, were prospectively assessed at weekly intervals for 6 months after birth for breast-feeding practices and RIF. We estimated the risk of an RIF episode for infants who were exclusively breast-fed the prior week compared with infants not exclusively breast-fed the prior week using generalized estimating equations. Results: We followed a total of 331 infants from birth to 24 weeks of age. The median weeks infants were exclusively breast-fed was 15 (interquartile range, 6-21). The adjusted independent odds of respiratory illness for exclusively breast-fed infants compared with nonexclusively breast-fed infants was 0.59 (95% confidence interval: 0.45-0.77) for an RIF episode. After adjusting for exclusive breast-feeding, we confirmed the previous report that maternal immunization with influenza vaccine had an independent protective effect against RIF (odds ratio, 0.72; 95% confidence interval: 0.55-0.93). No significant difference in the protective effect of exclusive breast-feeding was seen by maternal influenza immunization status. Conclusions: Exclusive breast-feeding during the first 6 months of life and maternal immunization with influenza vaccine independently and substantially reduced respiratory illness with fever in infants.
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