4.5 Article Proceedings Paper

Human Immunodeficiency Virus Diagnostic Testing of Infants at Clinical Sites in North America 2002-2006

期刊

PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 28, 期 7, 页码 614-618

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e31819ac33b

关键词

HIV; diagnostic testing; infants; North America

资金

  1. NIAID NIH HHS [U01AI068632, 1 U01 AI068616] Funding Source: Medline
  2. NICHD NIH HHS [N01-HD-3-3365] Funding Source: Medline
  3. NIDDK NIH HHS [N01-DK-8-0001] Funding Source: Medline
  4. PHS HHS [HHSN272200800014C, HHSN267200800001C] Funding Source: Medline

向作者/读者索取更多资源

Background: Our objectives were to assess the timing of testing, the types of diagnostic assays used, and the costs associated with the diagnosis of HIV-1 infection among infants born to HIV-1-infected women enrolled in the International Maternal Pediatric Adolescent AIDS Clinical Trials Group Protocol 1025 (P1025). Methods: P1025 is a prospective cohort study of HIV-1-infected women and their infants at clinical sites in the United States and Puerto Rico. Enrollment began in 2002 and is ongoing. Follow-up of infants continued for at least 6 months after delivery/birth. The study population for this analysis comprised all live born infants of known HIV-1 infection status, born by December 31, 2006 to enrolled women. Results: Nine hundred eighty-eight infants had 5147 HIV-1 diagnostic test results reported. The median number of HIV-1 diagnostic assays performed per infant was 5 (10th, 90th percentiles: 3, 7), and the greatest number of tests reported per infant was 13. The median ages at the time of the first, second, third, and fourth HIV-1 diagnostic assay were 0.1, 2.3, 7.0, and 17.6 weeks, respectively. Nucleic acid amplification tests (NAATs) represented 86.9% of all diagnostic assays (HIV-1 DNA PCR assays: n = 4082 [79.3%]; other NAATs: n = 389 [7.6%]). The median cost per infant for HIV-1 diagnostic testing was $1168 (10th 90th percentiles: $762, $1642). Conclusions: Most assays reported for HIV-1-exposed infants at clinical sites in the United States and Puerto Rico were NAATs, but the number of HIV-1 diagnostic assays performed per infant, and the cost associated with HIV-1 diagnostic testing per infant, varied greatly.

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