期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 27, 期 5, 页码 444-452出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e3181660c2e
关键词
live attenuated; cold adapted; trivalent; intranasal influenza vaccine; asthma; wheezing
资金
- NIAID NIH HHS [R01 AI041050, U01 AI041050, UO1AI41050] Funding Source: Medline
Background: Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with asthma is unknown. A previous report showed an asthma signal in children aged 18-35 months. Methods: Healthy children aged 1.5-18 years with history of intermittent wheezing received single annual LAIV doses during a 4-year trial. Rates of medically-attended acute respiratory illnesses, including acute asthma exacerbation, during 0-14 and 0-42 days post-LAIV were compared with respective reference periods (before day 0 and after 14 or 42 days). To assess the risk of new-onset asthma, LAIV recipients without history of wheezing were analyzed. Results: During each of the 4 years, 454, 656, 656, and 430 children, respectively, with intermittent wheezing who received LAW had no increased risk for medically-attended acute respiratory illnesses, including asthma exacerbation. First-dose LAIV recipients, including those aged 1.5-4 years, and those receiving 2-4 consecutive annual doses had no increased risk. Children with parents' report of intermittent wheezing and those with administrative database codes for asthma during 2 prior years had no increased risk. During the 4 years, 2952, 3092, 2953, and 2478 children without history of wheezing had no increased risk of new-onset asthma. Conclusions: LAW administration in children aged 1.5-18 years with history of intermittent wheezing was safe, and was not associated with increased risk for medically-attended acute respiratory illnesses, including acute asthma exacerbation. This was true for the first and 2-4 consecutive annual doses. Parents' report of intermittent wheezing was reliable. First-dose LAIV was not associated with new-onset asthma in children without history of wheezing.
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