期刊
PEDIATRIC HEMATOLOGY AND ONCOLOGY
卷 25, 期 1, 页码 73-78出版社
INFORMA HEALTHCARE
DOI: 10.1080/08880010701774033
关键词
1,25-dihydroxyvitamin D; dysgerminoma; humoral hypercalcemia of malignancy; hypercalcemia
Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25-dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
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