期刊
PEDIATRIC BLOOD & CANCER
卷 61, 期 5, 页码 885-893出版社
WILEY
DOI: 10.1002/pbc.24882
关键词
ALL; childhood cancer survivor; cholecalciferol; controlled trial; vitamin D
资金
- National Institutes of Health [P30 CA21765]
- Center of Excellence grant from the State of Tennessee
- Le Bonheur Foundation (Memphis TN)
- American Lebanese Syrian Associated Charities (ALSAC)
- NIH [R21 HD059292, GM 92666]
- Gabrielle's Angel Foundation
BackgroundWe sought to improve lumbar spine bone mineral density (LS-BMD) in long-term survivors of childhood acute lymphoblastic leukemia (ALL) using calcium and cholecalciferol supplementation. ProcedureThis double-blind, placebo-controlled trial randomized 275 participants (median age, 17 [9-36.1] years) with age- and gender-specific LS-BMD Z-scores <0 to receive nutritional counseling with supplementation of 1,000mg/day calcium and 800International Unit cholecalciferol or placebo for 2 years. The primary outcome was change in LS-BMD assessed by quantitative computerized tomography (QCT) at 24 months. Linear regression models were employed to identify the baseline risk factors for low LS-BMD and to compare LS-BMD outcomes. ResultsPre-randomization LS-BMD below the mean was associated with male gender (P=0.0024), White race (P=0.0003), lower body mass index (P<0.0001), and cumulative glucocorticoid doses of 5,000mg (P=0.0012). One hundred eighty-eight (68%) participants completed the study; 77% adhered to the intervention. Mean LS-BMD change did not differ between survivors randomized to supplements (0.330.57) or placebo (0.28 +/- 0.56). Participants aged 9-13 years and those 22-35 years had the greatest mean increases in LS-BMD (0.50 +/- 0.66 and 0.37 +/- 0.23, respectively). Vitamin D insufficiency (serum 25[OH]D <30ng/ml) found in 296 (75%), was not associated with LS-BMD outcomes (P=0.78). ConclusionCholecalciferol and calcium supplementation provides no added benefit to nutritional counseling for improving LS-BMD among adolescent and young adult survivors of ALL (93% of whom had LS-BMD Z-scores above the mean at study entry). Pediatr Blood Cancer 2014;61:885-893. (c) 2014 Wiley Periodicals, Inc.
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