期刊
PEDIATRIC BLOOD & CANCER
卷 62, 期 1, 页码 123-127出版社
WILEY-BLACKWELL
DOI: 10.1002/pbc.25206
关键词
cardiotoxicity; late effects of cancer treatment; pediatric oncology
BackgroundSubclinical cardiotoxicity occurs in childhood cancer survivors following moderate and high anthracycline doses. However, less is known about the subclinical changes in left ventricular (LV) structure that occur after very low anthracycline doses of 100mg/m(2). This study was designed to assess LV function and key structural parameters following very low doses of anthracycline. ProcedureConventional 2-dimensional echocardiograms with Doppler were obtained in 91 survivors of childhood cancer exposed to 100mg/m(2),an average of 9.8 years from diagnosis. LV structural measurements were converted into Z-scores. The Z-score distributions were compared to those of the normal population. Diastolic and systolic function were quantified. ResultsThe cohort demonstrated a decreased posterior wall thickness (mean Z-score -1.01) and mildly decreased LV end diastolic (mean Z-score -0.85) and systolic (mean Z-score -0.84) dimensions compared to the normal population (P<0.001). Further, 28% of patients (n=25) had abnormal LV posterior wall thickness, 2 standard deviations below the mean (Z-score -2). There were no patients with diastolic dysfunction or symptomatic systolic dysfunction, however four patients demonstrated abnormal SF28%. ConclusionsA significant proportion of patients exposed to very low doses of anthracycline demonstrate subclinical abnormalities in LV structure, despite the absence of radiation or other risk factors. While we cannot say whether these structural changes will result in clinically significant cardiac disease, the reported progressive nature of these findings raises concern that there may truly be no safe dose of anthracycline. Pediatr Blood Cancer 2015;62:123-127. (c) 2014 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据