期刊
PEDIATRIC BLOOD & CANCER
卷 55, 期 2, 页码 344-348出版社
WILEY
DOI: 10.1002/pbc.22500
关键词
AML; chemokines; paediatric haematology/oncology
资金
- Histiocytosis Association of America
- Dutch Cancer Society [RUL 2001-2515, UL 2005-3657]
Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer 2010;55:344-348. (C) 2010 Wiley-Liss, Inc.
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