期刊
PEDIATRIC BLOOD & CANCER
卷 53, 期 6, 页码 1136-1139出版社
WILEY
DOI: 10.1002/pbc.22142
关键词
acute myeloid leukemia; prognosis; prognostic factor; Wilms tumor 1
资金
- Ruth L. Kirschstein National Research Service Award (NRSA)
- Institutional Research Training [T32, 5T32CA060441-15]
- Children's Cancer Foundation
- NIH [CA 120535]
- Dr. Arceci is the King Falid Endowed Chair in Pediatric Oncology at Johns Hopkins
WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these Studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression. Pediatr Blood Cancer 2009;53:1136-1139. (C) 2009 Wiley-Liss, Inc.
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