期刊
PEDIATRIC ALLERGY AND IMMUNOLOGY
卷 25, 期 6, 页码 565-571出版社
WILEY-BLACKWELL
DOI: 10.1111/pai.12276
关键词
dietary patterns; children; asthma; atopy
资金
- Asthma UK [04/014]
- Moulton Charitable Trust
- MRC [G0601361]
- MRC [G0601361, MR/K002449/1, G0701918] Funding Source: UKRI
- Medical Research Council [G0601361, G0701918, MR/K002449/1] Funding Source: researchfish
BackgroundMany studies have investigated individual nutrients or foods as risk factors for allergic disease, but few have studied dietary patterns. We aimed to use principal component analysis (PCA) to determine dietary patterns in school age children and examine associations between these dietary patterns and wheeze, asthma and sensitization. MethodsParticipants in a population-based birth cohort attended review clinics at ages 8 and 11yr. A validated questionnaire was interviewer-administered to collect information on parentally reported symptoms and doctor-diagnosed asthma. Atopic sensitization was ascertained by skin-prick tests. Current asthma was defined as doctor-diagnosed asthma and wheezing in the previous 12months. A validated semi-quantitative food frequency questionnaire was completed at age 8yr, and PCA was used to determine dietary patterns. ResultsPrincipal component analysis identified three dietary components, which based on their characteristics we termed as Traditional (mixed meat, fish, fruit and vegetables), Western (predominantly high fat content, processed foods) and Other (predominantly grains and nuts) dietary patterns. High adherence to the Western diet pattern was significantly associated with doctor-diagnosed asthma and current asthma at age 8yr [aOR (95% CI): 2.19 (1.20-4.01), p=0.01; 2.59 (1.15-5.81), p=0.02; respectively]. A similar association was found for current asthma at age 11yr [aOR (95% CI): 2.20 (1.07-4.51), p=0.03]. There was no evidence of an association between dietary patterns and current wheeze and allergic sensitization at either age 8 or 11yr. ConclusionSchool age children adhering strongly to a Western diet, high in fat and processed foods, had a higher risk of current asthma and doctor-diagnosed asthma.
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