期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 209, 期 5, 页码 269-275出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.prp.2013.01.009
关键词
Breast cancer; Tumor budding; EMT; Prognosis
类别
资金
- Science and Technology Planning Project of Shaanxi Province, China [S2010SF855]
- Natural Science Foundation of Shaanxi Province, China [SJ08-ZT09]
We investigated the prognostic value of tumor budding in 160 cases of operable invasive ductal carcinoma, not otherwise specified (IDC-NOS). The number of buds was counted in H&E slides with a maximal invasive margin in a 0.950 mm(2) field of vision (200 x). According to a cut-off score selected by ROC analysis, the cohort was dichotomized into a low (0-7 budding foci, 107 cases, 66.9%) and a high-grade budding group (8 or more budding foci, 53 cases, 33.1%). The inter-observer test showed a good reproducibility with 0.717 as the K value. High-grade budding was significantly associated with the presence of lymphovascular invasion (LVI) (P=0.001), larger tumor size (P=0.014), and worse clinical outcome (P < 0.001). By immunohistochemical staining, budded cells at the margin displayed epithelial mesenchymal transition (EMT)-like molecular phenotype and decreased proliferative activity. Survival analyses revealed that tumor budding (HR 4.275, P < 0.001) together with tumor size (HR 2.468, P=0.002), node status (HR 2.362, P < 0.001), and LVI status (HR 1.910, P=0.035) was the independent prognostic factor in IDC-NOS. In conclusion, tumor budding is a reproducible, significant, and independent histopathological prognostic factor in IDC-NOS. (C) 2013 Elsevier GmbH. All rights reserved.
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