期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 204, 期 11, 页码 785-792出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.prp.2008.06.006
关键词
PAG/Cbp; Src-kinases; Ras; Cytoskeleton-oncogenesis
类别
Engagement of plasma membrane receptors is followed by an assembly of a multimolecular complex of signaling molecules organized by scaffolding or adaptor proteins. PAG is a recently characterized transmembrane adaptor protein associated with lipid rafts, which is involved in the regulation of Src-kinases, monomeric Ras protein, and interactions with the cytoskeleton. The review provides up-to-date information about the protein that attracts increasing attention in current biomedical research. (C) 2008 Elsevier GmbH. All rights reserved.
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