期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 204, 期 2, 页码 77-88出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.prp.2007.10.013
关键词
cilia; ciliary dysfunctions; mouse model; treatment
类别
Abnormal visceral patterning has been known for centuries. However, it has not been associated with ciliary dysfunction until recently. Overlapping clinical entities including situs inversus, certain infertility disorders, as well as chronic respiratory infections have their roots in abnormal ciliary function. Current research focuses on causative factors and genes involved in signal transduction pathways that define ciliary function and structure, as well as treatment. In this review, attempts are made to outline selected, yet key topics related to ciliary function in health and disease. (C) 2007 Elsevier GmbH. All rights reserved.
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