期刊
PATHOLOGIE BIOLOGIE
卷 57, 期 4, 页码 336-341出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.patbio.2008.09.007
关键词
Skin; Aging; Fibroblasts; Keratinocytes; Extracellular matrix; Elastases; Free radicals; Maillard reaction; Receptors
类别
Skin is the most voluminous organ of the body. It assumes several important physiological functions and represents also a social interface between an individual and other members of society. This is the main reason its age-dependent modifications are in the forefront of dermatological research and of the anti-aging cosmetic industry. Here we concentrate on some aspects only of skin aging, as far as the cellular and extracellular matrix components of skin are concerned. Most well studied mechanisms of skin aging can be situated at the postgenetic level, both epigenetic and post-translational mechanisms being involved. Some of these mechanisms will be reviewed as well as the capacity of fucose- and rhamnose-rich oligo- and polysaccharides (FROP and RROP) to counteract several of the mechanisms involved in skin aging. (C) 2008 Elsevier Masson SAS. All rights reserved.
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