期刊
PATHOBIOLOGY
卷 75, 期 2, 页码 119-131出版社
KARGER
DOI: 10.1159/000123850
关键词
breast carcinoma; basal-like carcinoma; microarrays; molecular classification of tumors; immunohistochemistry
This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results and statistical analysis. The review concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers, but show significant variations in their phenotypes, grades, immunoprofiles and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Well-designed studies with comparison of low-grade nonbasal versus low-grade basal and high-grade nonbasal versus high-grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathological entity. Copyright (c) 2008 S. Karger AG, Basel.
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