期刊
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
卷 31, 期 12, 页码 1204-1222出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201400140
关键词
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资金
- NC TraCS [550KR51307]
- NIH's Clinical and Translational Science Awards [1UL1TR001111]
- NC State Faculty Research and Professional Development Award
- Joint BME Department of UNC-CH
- NCSU
Proteins exhibiting anticancer activities, especially those capable of discriminately killing cancer cells, have attracted increasing interest in developing protein-based anticancer therapeutics. This Progress Report surveys recent advances in delivering anticancer proteins directly to tumor tissue for inducing apoptosis/necrosis or indirectly to antigen presenting cells for provoking immune responses. Protein delivery carriers such as inorganic particles, lipid particles, polymeric particles, DNA/protein-based biomacro-molecular particles, as well as cell based carriers are reviewed with comments on their advantages and limitations. Future challenges and opportunities are also discussed.
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