期刊
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
卷 31, 期 4, 页码 481-491出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201300223
关键词
BODIPY; tetraphenylethene; biological imaging; nanoparticle; aggregation-induced emission
资金
- National Natural Science Foundation of China [51273053, 21104012]
- Natural Science Foundation of Zhejiang Province [Y4110331]
- Program for Changjiang Scholars and Innovative Research Teams in Chinese Universities [IRT 1231]
- National Basic Research Program of China (973 Program) [2013CB834702]
- Project of Zhejiang Key Scientific and Technological Innovation Team [2010R50017]
- CONACyT [132946]
- Singapore National Research Foundation [R279-000-390-281]
- Guangdong Innovative Research Team Program of China [20110C0105067115]
- Research Grants Council of Hong Kong [HKUST2/CRF/10]
BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) is an emissive chromophore in solutions but suffers from fluorescence quenching when aggregated due to its flat molecular conformation and small Stokes shift. To create aggregate-state emissive BODIPY luminogens, tetraphenylethene (TPE), which is a popular luminogen with intriguing aggregation-induced emission (AIE) characteristic, is introduced as periphery to a methylated BODIPY core. Three TPE-BODIPY adducts are synthesized and characterized, and their photophysical properties and electronic structures are investigated. The incorporation of AIE-active TPE units alleviates aggregation-caused quenching of BODIPY core, furnishing emissive nanoparticles based on TPE-BODIPY adducts. Significantly, the two-photon absorption (TPA) and two-photon excited fluorescence (TPEF) properties are improved as more TPE units are attached. The luminogens with 3TPE units (3TPE-BODIPY) shows the strongest TPA and TPEF in the wavelength range of 750-830 nm, with cross-section values of 264 and 116 GM at 810 nm, respectively. Red emissive nanoparticles with a Stokes shift of 60 nm and a fluorescence quantum yield of 16% are attained by encapsulating 3TPE-BODIPY with 1,2-sistearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]. The nanoparticles are biocompatible and function well in TPEF cellular imaging and mouse brain blood vascular visualization.
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