Synthesis, solid state structures and urease inhibitory activities of two silver(I) complexes with 1,4-benzodioxane-6-carboxylate

Two new silver(I) complexes, namely [Ag-2(BZDO)(2)(H2O)] (1) and {[Ag(bipy)(BZDO)]center dot[Ag(bipy)(H2O)](BZDO)center dot 4(H2O)} (n) (2) (BZDOH = 1,4-benzodioxane-6-carboxylic acid, bipy = 4,4'-bipyridine), were synthesized and structurally characterized. Single-crystal X-ray analysis reveals that complex 1 has a discrete dinuclear silver(I) unit, [Ag-2(BZDO)(2)(H2O)], in which just one water molecule is located in the axial region and two silver atoms are further clamped by a pair of BZDO ligands in a A mu (2)-eta (1):eta (1) bridging coordination mode (Ag center dot center dot center dot Ag = 2.8106(10) ). Complex 2 consists of an [Ag(bipy)(BZDO)] (n) chain, an [Ag(bipy)(H2O)] (n) (n+) cationic chain, a one-dimensional ladder-like anionic chain formed by uncoordinated BZDO ligands and free water molecules. Both 1 and 2 show potent urease inhibitory activities with the respective IC50 values of 1.60 +/- A 0.06 and 1.42 +/- A 0.09 mu M.