期刊
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
卷 30, 期 2, 页码 117-132出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201200129
关键词
self-assembly; DNA; mono-functionalization; nanoparticle; nano-building blocks; programmable matter; multifunctional nanostructure; nanotechnology; nanomedicine; nano-theranostics
资金
- National Science Foundation [CMMI 1235100, 0709121, ECCS 1137948, 1128660, CCF 1049719, 0523858]
- Arkansas Biosciences Institute
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1315129] Funding Source: National Science Foundation
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [0523858] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0709121] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1128660] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1235100] Funding Source: National Science Foundation
The assembly of nanoparticles into complicated, anisotropic shapes has much promise for advanced materials and devices. Developing effective and efficient anisotropic mono-functionalization strategies is an imperative step in realizing this potential. By functionalizing DNA one at a time to the nanoparticle, a DNA-nanoparticle building block could have distinct DNA sequences at different locations on the surface of the particle. Since this technology could incorporate nanoparticles of different composition, generating toolboxes of various nanoparticle building blocks (nano-toolboxes) with DNA at defined locations and in defined 3D orientations on a nanoparticle, it promises not only complicated shapes, but also the ability to tune the function of the assembly. The challenges of programmable and scalable multifunctional nanostructure self-assembly with DNA conjugated to nanoparticles are reviewed. The first difficulty is to control the assembly process so that designed products are formed, and unwanted products are minimized. The design problem for nanostructure construction is both physically and computationally complex. Thus, the other major challenge is to devise design methodologies that move nanostructure construction from trial and error to principled approaches. Strategies to overcome these challenges are also presented by realizing greater control over the final shapes and functions of the self-assembled nanostructures. Finally, the future perspectives of nano-toolboxes and their promise in applications such as multifunctional, multicolor, and multimodal contrast nanoagents for medical therapy and diagnostics (theranostics) are described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据