期刊
PARKINSONISM & RELATED DISORDERS
卷 16, 期 9, 页码 600-603出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2010.08.016
关键词
Parkinson disease; Deep brain stimulation; Transcranial Doppler; Neurovascular coupling; Autonomic function; Cerebral hemodynamics
Background and Purpose In Parkinson s disease (PD) subthalamic nucleus deep brain stimulation (STN-DBS) improves motor function Also an effect on the neurovascular coupling in motor cortex was reported due to a parallel activation of a subthalamic vasodilator area (SVA) To address this issue further we analysed neurovascular coupling in a non-motor area Methods Twenty PD patients selected for bilateral STN-DBS were investigated with functional transcranial Doppler (f-TCD) before and after surgery Hemodynamic responses to visual stimulation were registered in left posterior cerebral artery (PCA) and analysed with a control-system approach (parameters gain rate time attenuation and natural frequency) To exclude autonomic effects of STN-DBS we also addressed spectrum analysis of heart rate and of systolic arterial blood pressure variability and baroreceptor gain Findings in the PD group were compared with healthy age-matched controls Results PD patients showed no neurovascular coupling changes in PCA territory compared to controls and STN-DBS changed neither blood flow regulatory parameters nor autonomic function Conclusions Improvement of vasoregulation in some motor cortical areas after STN-DBS might be related to an Improved neuronal functional rather than indicating an effect on the neurovascular coupling or autonomic function (C) 2010 Elsevier Ltd All rights reserved
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