期刊
PARKINSONISM & RELATED DISORDERS
卷 15, 期 -, 页码 S162-S166出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1353-8020(09)70806-5
关键词
Cerebellin1; Dendritic spine; Dopamine; Medium spiny neuron; Parkinson's disease; Parafascicular nucleus; Thalamus
资金
- National Institutes of Health [F31 NS061528, R01 RR00165, CA21765, NS040361, NS042828, NS051537, PO1 NS44282]
- Department of Veterans Affairs
- American Lebanese Syrian Associated Charities
- National Parkinson Foundation Center of Excellence at Vanderbilt
Neuronal loss in Parkinson's disease (PD) is more widespread than originally thought. Among the extrastriatal sites in which significant loss of neurons has been reported is the centremedian-parafascicular (CM-PF) complex of the thalamus, which provides one of the three major afferent sources to the striatum. The functional significance of CM-PF loss in PD is unclear. Interestingly, several recent small trials have suggested that deep brain stimulation of the CM-PF improves motor function in PD. We discuss the possible transsynaptic determination of CM-PF loss secondary to nigrostriatal dopamine degeneration, and suggest that expression of the glycoprotein cerebellin1 (Cbln1) in CM-PF neurons may play an important role in striatal synaptic remodeling in parkinsonism. (C) 2009 Elsevier Ltd. All rights reserved.
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