期刊
PARKINSONISM & RELATED DISORDERS
卷 15, 期 8, 页码 602-605出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2008.11.006
关键词
Essential tremor; Epidemiology; Leg tremor; Correlates; Case control study; Clinical
资金
- National Institutes of Health (Bethesda, MD) [R01 NS039422, RR00645]
- Columbia University
The hallmark feature of essential tremor (ET) is action tremor of the arms. Leg tremor may also occur yet it has not been the central focus of previous studies. Its prevalence has only rarely been reported its, clinical correlates have yet to be explored. Our aims were to report the prevalence and analyze the clinical correlates of leg action tremor in patients with ET and, given the propensity for normal elderly individuals to manifest mild limb tremors, compare the prevalence with that in age-matched controls. Kinetic leg tremor rated >= 1 occurred in 28/63 (44.4%) ET cases and in only 9/63 (14.3%) controls (p < 0.001); moderate leg tremor occurred in 14.3% of cases. Leg tremor severity modestly correlated with disease duration (r = 0.31, p = 0.02). However, the severity and laterality of leg tremor did not correlate with those of arm tremor. The pathophysiological implications of this finding deserve further exploration. (C) 2008 Elsevier Ltd. All rights reserved.
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