期刊
PARKINSONISM & RELATED DISORDERS
卷 14, 期 1, 页码 46-51出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2007.05.013
关键词
Parkinson's disease; innate immunity; natural killer (NK); NKG2A; NKG2D
Neuroinflammation in Parkinson's disease (PD) involves activation of microglia, participation of several inflammatory cytokines, prostaglandins, complement and systemic activation of natural killer (NK) cells, suggesting that innate immunity has a role in the pathogenesis of this disease. In this study, we examined NK activity and the expression of its regulatory molecules in peripheral lymphocytes of PD patients and compared the results with those of healthy controls. Expression of the inhibitory NKG2A receptors was significantly lower in PD, causing PD patients to be susceptible in a condition for NK activation after NK cells bind to target cells via these receptors. (C) 2007 Elsevier Ltd. All rights reserved.
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