期刊
PARASITOLOGY RESEARCH
卷 113, 期 8, 页码 3105-3109出版社
SPRINGER
DOI: 10.1007/s00436-014-4015-5
关键词
Mosquito vector; Medicinal plant; NMR; Larvicide; Histopathology
类别
资金
- Department of Biotechnology (DBT), Government of India [PR13126/GBD/27/194/2009]
In the present investigation, the effective root compound of plumbagin of Plumbago zeylanica (Plumbaginaceae) was evaluated for chemical constituent and antimalarial effect against the fourth instar larvae of Anopheles stephensi Liston (Diptera). In the chromatographic analyses of root compound with Rf value of 0.788 and NMR analyses also revealed that the effective compound contain naphthoquinone plumbagin were identified as the major chemical constituent. Larval mortality was observed after 3 h of exposure period. The plumbagin compound showed remarkable larvicidal activity against A. stephensi (LC50 32.65 and LC(90)72.27 ppm). Histopathological effects of compound was observed in the treated larvae. Based on the results, the plumbagin compound of P. zeylanica can be considered as a new source of natural larvicide for the control of malarial vector.
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