期刊
PARASITOLOGY INTERNATIONAL
卷 61, 期 1, 页码 32-37出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2011.07.020
关键词
Opisthorchis viverrini sensu lato; Systematic; Genetic variation; Population genetics; Opisthorchiasis; Cholangiocarcinoma
类别
资金
- Thailand Research Fund Basic Research Grant
- Faculty of Medicine, Khon Kaen University
- Office of the Higher Education Commission, through the Health Cluster (SHeP-GMS), Khon Kaen University
Together with host and environmental factors, the systematics and population genetic variation of Opisthorchis viverrini may contribute to recorded local and regional differences in epidemiology and host morbidity in opisthorchiasis and cholangiocarcinoma (CCA). In this review, we address recent findings that O. viverrini comprises a species complex with varying degrees of population genetic variation which are associated with specific river wetland systems within Thailand as well as the Lao PDR. Having an accurate understanding of systematics is a prerequisite for a meaningful assessment of the population structure of each species within the O. viverrini complex in nature, as well as a better understanding of the magnitude of genetic variation that occurs within different species of hosts in its life cycle. Whether specific genotypes are related to habitat type(s) and/or specific intermediate host species are discussed based on current available data. Most importantly, we focus on whether there is a correlation between incidence of CCA and genotype(s) of O. viverrini. This will provide a solid basis for further comprehensive investigations of the role of genetic variation within each species of O. viverrini sensu lato in human epidemiology and genotype related morbidity as well as co-evolution of parasites with primary and secondary intermediate species of host. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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