期刊
PARASITOLOGY INTERNATIONAL
卷 59, 期 3, 页码 407-413出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2010.05.007
关键词
Strongyloides fuelleborni; Strongyloides stercoralis; Molecular identification; Phylogeny; Diversity; Primates; Humans; Africa; Japan
类别
资金
- Japan Society for Promotion of Sciences [19580355, 20570090]
- Morinaga Service Foundation, Tokyo
- Ministry of the Environment [GERF-061]
- Grants-in-Aid for Scientific Research [19580355, 20570090, 22580349] Funding Source: KAKEN
In order to identify the causative agent of imported strongyloidiasis found in a Japanese mammalogist, who participated in a field survey in Tanzania, the hyper-variable region IV (HVR-IV) of 18S ribosomal DNA and partial mitochondrial cytochrome c-oxidase subunit 1 gene (cox1) were analyzed and compared with Strongyloides fuelleborni collected from apes and monkeys of Africa and Japan, and S. stercoralis from humans, apes and dogs. The HVR-IV and cox1 of the patient's worms were identical to or only slightly differed from those of worms parasitic in Tanzanian chimpanzees and yellow baboons, demonstrating that the patient acquired the infection during her field survey in Tanzania. Phylogenetic analysis with the maximum-likelihood method largely divided isolates of S. fuelleborni into three groups, which corresponded to geographical localities but not to host species. Meanwhile, isolates of S. stercoralis were grouped by the phylogenetic analysis into dog-parasitic and primate-parasitic clades, and not to geographical regions. It is surmised that subspeciation has occurred in S. fuelleborni during the dispersal of primates in Africa and Asia, while worldwide dispersal of S. stercoralis seems to have occurred more recently by migration and the activities of modern humans. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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