相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Antimalarial pharmacology and therapeutics of atovaquone
Gemma L. Nixon et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)
HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc1 Complex
Cindy Vallieres et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Exploration of 4(IH)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bcl
Jose M. Bueno et al.
FUTURE MEDICINAL CHEMISTRY (2012)
Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc1 Catalytic Turnover and Protein Expression
Nicholas Fisher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases
Paul T. P. Bedingfield et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Suet C. Leung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase
Alka Marwaha et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Chandrakala Pidathala et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials
Yiqun Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
The global pipeline of new medicines for the control and elimination of malaria
Melinda P. Anthony et al.
MALARIA JOURNAL (2012)
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
Giancarlo A. Biagini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor
Tae-gyu Nam et al.
ACS CHEMICAL BIOLOGY (2011)
Conformationally linked interaction in the cytochrome bc1 complex between inhibitors of the Qo site and the Rieske iron-sulfur protein
Edward A. Berry et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2011)
Potent antimalarial 4-pyridones with improved physico-chemical properties
Jose M. Bueno et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors
Carolyn K. Dong et al.
CHEMISTRY & BIOLOGY (2011)
Optimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure-Activity and Structure-Property Relationships
R. Matthew Cross et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Jose M. Coteron et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice
Ramesh Gujjar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Inhibitors of the Mitochondrial Electron Transport Chain and de novo Pyrimidine Biosynthesis as Antimalarials: The Present Status
T. Rodrigues et al.
CURRENT MEDICINAL CHEMISTRY (2010)
Inhibiting Plasmodium cytochrome bc1: a complex issue
Victoria Barton et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model
Michael L. Booker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Current Trends in Ligand-Based Virtual Screening: Molecular Representations, Data Mining Methods, New Application Areas, and Performance Evaluation
Hanna Geppert et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
Endochin Optimization: Structure-Activity and Structure-Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity
R. Matthew Cross et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes
Maria Belen Jimenez-Diaz et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds
Xiaoyi Deng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases
Matthew Davies et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice
Ramesh Gujjar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Discovery of dual function acridones as a new antimalarial chemotype
Jane X. Kelly et al.
NATURE (2009)
Artemisinin Resistance in Plasmodium falciparum Malaria.
Arjen M. Dondorp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase
Nicholas A. Malmquist et al.
BIOCHEMISTRY (2008)
Identification and Characterization of Small Molecule Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase
Vishal Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum
Margaret A. Phillips et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
The malaria parasite type IINADH:quinone oxidoreductase:: an alternative enzyme for an alternative lifestyle
Nicholas Fisher et al.
TRENDS IN PARASITOLOGY (2007)
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
Heather J. Painter et al.
NATURE (2007)
Mitochondrial drug targets in apicomplexan parasites
Michael W. Mather et al.
CURRENT DRUG TARGETS (2007)
Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor
Hong Xiang et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Similarity-based virtual screening using 2D fingerprints
Peter Willett
DRUG DISCOVERY TODAY (2006)
Evaluation and lead optimization of anti-malarial acridones
Rolf W. Winter et al.
EXPERIMENTAL PARASITOLOGY (2006)
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria
GA Biagini et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Dual binding mode of a novel series of DHODH inhibitors
R Baumgartner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
T Heikkila et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J Baldwin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase
AN Boa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
PowerMV: A software environment for molecular viewing, descriptor generation, data analysis and hit evaluation
KJ Liu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)
Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir
ES Furfine et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Molecular basis for atovaquone binding to the cytochrome bc1 complex
JJ Kessl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Malarial dihydroorotate dehydrogenase
J Baldwin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Reoptimization of MDL keys for use in drug discovery
JL Durant et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2002)
Genome sequence of the human malaria parasite Plasmodium falciparum
MJ Gardner et al.
NATURE (2002)
Rapid method for the estimation of octanol/water partition coefficient (log Poct) from gradient RP-HPLC retention and a hydrogen bond acidity term (Σα2H)
K Valko et al.
CURRENT MEDICINAL CHEMISTRY (2001)
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase
JE McLean et al.
BIOCHEMISTRY (2001)
In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs
JB Dressman et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2000)
Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents
SP Liu et al.
STRUCTURE WITH FOLDING & DESIGN (2000)