期刊
PARASITOLOGY
卷 136, 期 12, 页码 1403-1413出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182009005782
关键词
tick-borne pathogens; tick saliva; immunomodulation; alternative complement; transmission potential; human exposure; epidemiology
类别
资金
- EU [GOCE-2003-010284]
- EDEN Steering Committee [EDEN0128]
This review focuses on some of the more ground-shifting advances of recent decades, particularly those at the molecular and cellular level that illuminate mechanisms underpinning the natural ecology of tick-host-pathogen interactions and the consequent epidemiology Of zoonotic infections in humans. Knowledge of components of tick saliva, now recognized as the central pillar in the tick's ability to complete its blood meal and the pathogen's differential ability to use particular hosts for transmission, has burgeoned with new molecular techniques. Functional Studies have linked a few of them to saliva-assisted transmission of non-systemic infections between co-feeding ticks, the quantitative key to persistent cycles of the most significant tick-borne pathogen in Europe. Human activities, however, may be equally important in determining dynamic patterns of infection incidence in humans.
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