期刊
PARASITOLOGY
卷 137, 期 4, 页码 685-696出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182009991399
关键词
nematodes; tannins; browse plants; natural anthelmintic; sheep
类别
资金
- EU Marie Curie [MRTN-CT-2006-035805]
The anthelmintic properties of tannin-rich plants are being explored as an alternative to chemical drugs. lost data have been acquired on legume forages, but only few on browse plants. The present study aimed to (i) screen the in vitro, effects of extracts from 7 Mediterranean plants on Haemonchus contortus, (ii) verify the role of tannins using an inhibitor, polyvinyl polypyrrolidone (PVPP) and (iii) verify the in in vivo effects of extracts from 4 plants. Significant inhibition was shown in vitro using a larval migration inhibition (LMI) assay for all extracts except that from Olea europaea var. koroneiki. After adding PVPP, the LMI values were restored to control levels for all plants except Pistacia lentiscus and Ceratonia siliqua, confirming a role for tannins in the activity. In the in vivo experiment, 48 lambs composed 6 groups, depending on diet. On Day 0, groups G1-G5 received H. contortus and Trichostrongylus colubriformis larvae and C6 remained uninfected. The various diets were distributed from Days 14 to 45: P. lentiscus Quercus coccifera (G2), C. siliqua (G3). Onobrychis vicaiifolia (G4), or Medicago sativa for the 2 control groups (G5, G6). Egg excretion, packed cell volumes (PCVs) and inorganic phosphate were measured weekly throughout the entire experimental period. At slaughter, the worms were enumerated and their fecundity assessed. Consumption of the 4 browser plants did not provoke differences in pathophysiological measurements but there were significant decreases in egg excretion, mainly explained by significant decreases in worm fecundity for both species, without any statistical difference in worm numbers.
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