期刊
PARASITE
卷 15, 期 4, 页码 573-579出版社
EDP SCIENCES S A
DOI: 10.1051/parasite/2008154573
关键词
Schistosoma mansoni; insulin receptor; glucose; tyrosine kinase inhibitor
类别
资金
- Institut National de la Sante et de la Recherche Medicale (INSERM-FIOCRUZ program)
- Institut Pasteur de Lille
- Ministere de l'Education Nationale et de la Recherche
Very little is known about insulin signalling in schistosomes despite its potential importance in host-parasite molecular dialogue and parasite growth and development. The recent characterization of two insulin receptors (SmIR-1 and SmIR-2) in Schistosoma mansoni has led us to reconsider the question of the potential importance of insulin in host-schistosome interactions. In this work, we demonstrated that insulin could regulate glucose uptake in schistosomes and we investigated the implication of SmIR-1 and SmIR-2 in this process. The possibility that specific inhibitors of SmIR-1 and SmIR-2 tyrosine kinase activities could be developed to target schistosomes is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据