期刊
ACTA HISTOCHEMICA
卷 117, 期 4-5, 页码 379-385出版社
ELSEVIER GMBH
DOI: 10.1016/j.acthis.2015.02.013
关键词
Mammary gland; Embryogenesis; Development; Endocrine signals
类别
资金
- FIR, University of Catania, Italy
The aim of this review is to focus on the molecular factors that ensure the optimal development and maintenance of the mammary gland thanks to their integration and coordination. The development of the mammary gland is supported, not only by endocrine signals, but also by regulatory molecules, which are able to integrate signals from the surrounding microenvironment. A major role is certainly played by homeotic genes, but their incorrect expression during the spatiotemporal regulation of proliferative, functional and differentiation cycles of the mammary gland, may result in the onset of neoplastic processes. Attention is directed also to the endocrine aspects and sexual dimorphism of mammary gland development, as well as the role played by ovarian steroids and their receptors in adult life. (C) 2015 Elsevier GmbH. All rights reserved.
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