期刊
PARASITE IMMUNOLOGY
卷 31, 期 1, 页码 20-31出版社
WILEY
DOI: 10.1111/j.1365-3024.2008.01066.x
关键词
B lymphocyte; malaria; immunological memory; mouse
资金
- Medical Research Council [MC_U117584248] Funding Source: Medline
- MRC [MC_U117584248] Funding Source: UKRI
Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells with phenotypic characteristics of memory cells (CD19 IgD(-) CD38, IgG1) are generated in a primary Plasmodium chabaudi chabaudi infection of mice. In addition, we observed that germinal centre cells (CD19(+), GL7(+), MHCIIhi) and Marginal Zone B cells (CD19(+)CD23(-)IgD(-)) show faster expansion on re-infection than in the primary, though other subsets do not. Interestingly, though both IgM(-) and IgM(+) memory cells are produced, IgM(+) memory cells do not expand on second infection. The second infection quickly produced mature bone marrow plasma cells (intracellular Ig(hi), CD138(hi), CD9(+), B220(-)), compared to primary infection; which generates a very large population of immature splenic plasma cells (B220+). This analysis suggests that a memory B cell population is generated after a single infection of malaria, which on re-infection responds quickly producing germinal centres and generating long-lived plasma cells making the second encounter with parasite more efficient.
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