期刊
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
卷 109, 期 4, 页码 268-274出版社
OXFORD UNIV PRESS
DOI: 10.1093/trstmh/trv006
关键词
Brazil; Dengue; Fatal cases; Laboratorial diagnosis; Surveillance
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/CNPq [305333/2012-7]
- Programa Estrategico de Pesquisa em Saude/PAPES VI-FIOCRUZ [407690/2012-3]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro /FAPERJ [210.026/2014]
- Oswaldo Cruz Foundation/FIOCRUZ
- Brazilian Ministry of Health
Background: Rio de Janeiro (RJ) has been of major importance for the epidemiology of dengue viruses (DENVs) in Brazil. After the DENV 1-4 introductions in 1986, 1990, 2000 and 2011, respectively, the state has suffered explosive epidemics. We aimed to describe laboratorial, epidemiological and clinical aspects due to the emergence and re-emergence of distinct DENV in a 2-year period. Methods: Suspected dengue cases (n = 2833), including 190 fatal cases, were submitted to virus isolation, RT-PCR and non-structural 1 (NS1) antigen capture ELISA, IgM antibody-capture (MAC)-ELISA and IgG-ELISA. Results: Case confirmation was 47.5%. MAC-ELISA confirmed 32.6% of the cases, RT-PCR confirmed 56.3%; DENV was recovered in 33.1% of samples inoculated and NS1 ELISA confirmed 27.5% of the cases. DENV-2 was prevalent in 2010, DENV-1 in 2011 and DENV-4 in 2012. Individuals infected by DENV-3 and over 65 years-old, and children 15 years-old and under infected by DENV-2 had a significantly higher risk of developing a severe disease. Fatal cases confirmed (n=67) were due to DENV-1 (26.8%), DENV-2 (14.9%), DENV-3 (2.9%) and DENV-4 (7.4%). Conclusions: It has been shown here that viral emergences or re-emergences may play different roles in the disease epidemiology, especially when many serotypes co-circulate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据