期刊
PAIN MEDICINE
卷 9, 期 8, 页码 1217-1223出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1526-4637.2008.00470.x
关键词
Fabry Disease; Detection; Pain; Somatosensory Profile; Small-Fiber Sensory Neuropathy
资金
- DFG [Ba1921]
- BMBF [01EM0504, 01EM0506]
Fabry disease (FD) is an X-linked lipid storage disorder showing a high prevalence and early occurrence of painful neuropathy. Early detection of this likely underdiagnosed disease is an important approach because a causal therapy is available. We used a quantitative sensory testing to determine the detailed somatosensory profile of male Fabry patients and compare this profile with somatosensory profiles of other painful sensory neuropathies (SN). Within this pilot-study, the profile revealed a small-fiber sensory neuropathy selectively affecting C- and A-delta fibers. The comparison with different somatosensory profiles of painful SN, including painful small-fiber sensory neuropathies of other etiologies, showed that the FD profile differs significantly and is characterized by a severe impairment of thermal and preserved vibratory and mechanical discrimination. Thus, somatosensory profiling in male patients with painful extremities may be useful in the detection of FD.
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