期刊
PAIN
卷 154, 期 10, 页码 1946-1952出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2013.04.009
关键词
Preterm; Magnetoencephalography; Neural oscillation; Neonatal pain; Cognitive outcome; Spontaneous brain activity; Visual perception; Prematurity; Spontaneous brain activity; Child development; Resting-state; Pain; Cognition; Perception; Development
资金
- Kennedy Shriver Institute of Child Health and Human Development (NICHD/NIH) [RO1 HD039783]
- Child and Family Research Institute
- BC Leading Edge Endowment Fund (BC LEEF)
Children born very prematurely (<= 32 weeks) often exhibit visual-perceptual difficulties at school-age, even in the absence of major neurological impairment. The alterations in functional brain activity that give rise to such problems, as well as the relationship between adverse neonatal experience and neurodevelopment, remain poorly understood. Repeated procedural pain-related stress during neonatal intensive care has been proposed to contribute to altered neurocognitive development in these children. Due to critical periods in the development of thalamocortical systems, the immature brain of infants born at extremely low gestational age (ELGA; <= 28 weeks) may have heightened vulnerability to neonatal pain. In a cohort of school-age children followed since birth we assessed relations between functional brain activity measured using magnetoencephalogragy (MEG), visual-perceptual abilities and cumulative neonatal pain. We demonstrated alterations in the spectral structure of spontaneous cortical oscillatory activity in ELGA children at school-age. Cumulative neonatal pain-related stress was associated with changes in background cortical rhythmicity in these children, and these alterations in spontaneous brain oscillations were negatively correlated with visual-perceptual abilities at school-age, and were not driven by potentially confounding neonatal variables. These findings provide the first evidence linking neonatal pain-related stress, the development of functional brain activity, and school-age cognitive outcome in these vulnerable children. (C) 2013 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据