期刊
PAIN
卷 153, 期 3, 页码 651-656出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2011.11.029
关键词
Migraine; Diffusion tensor imaging; MRI; Tract-Based Spatial Statistics
资金
- Neuroscience Research Group of the Hungarian Academy of Sciences and University of Szeged
- Medical Research Council [ETT 026-04]
- Hungarian Academy of Sciences
- Center of Excellence at the University of Szeged [TAMOP-4.2.1/B-09/1/KONV-2010-0005]
- European Federation of Neurological Societies Department
Migraine is a common and disabling neurological disease. The pathomechanism that underlies the disorder is not entirely understood, and reliable biomarkers are missing. In the current analysis we looked for microstructural alterations of the brain white matter in migraine patients by means of diffusion-weighted magnetic resonance imaging. The measurements were carried out with a novel approach based on fine-tuned nonlinear registration and nonparametric permutation test in an alignment-invariant tract representation (Tract-Based Spatial Statistics). We found reduced fractional anisotropy in the right frontal white matter cluster of migraine patients. In the same region we also found increased mean diffusivity and increased radial diffusivity. The probabilistic tractography showed connection of this cluster to other parts of the pain network (orbitofrontal cortex, insula, thalamus, dorsal midbrain). We speculate that these findings reflect maladaptive plastic changes or white matter disintegration. (C) 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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