期刊
PAIN
卷 145, 期 3, 页码 358-363出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2009.07.018
关键词
Pain; Eye; Light; Noxious; Cornea; Uvea; Ophthalmic; Human; Unpleasant; Unpleasantness; Trigeminal ganglion; Trigeminal nucleus; Ventroposteromedial thalamus; Ventromedial posterior thalamus
资金
- NINDS [NS042721, NS064050]
Photophobia, or painful oversensitivity to light, occurs in a number of clinical conditions, which range from superficial eye irritation to meningitis. In this case study, a healthy subject with transient photophobia (induced by the overuse of contact lenses) was examined using functional magnetic resonance imaging (fMRI). While being scanned in a darkened environment, the subject was presented with intermittent 6-s blocks of bright light. The subject was scanned twice, once during his photophobic state and once after recovery. The subject reported that the visual stimuli produced pain (pain intensity = 3/10 and unpleasantness = 7/10) only during the photophobic state. During photophobia, specific activation patterns in the trigeminal system were seen at the level of the trigeminal ganglion, trigeminal nucleus caudalis, and ventroposteromedial thalamus. The anterior cingulate cortex, a brain structure associated with unpleasantness, was also active during photophobia. After recovery from photophobia, no significant activations were detected in these areas. This study may contribute to a better understanding of the pathways involved in photophobia in the human condition. (C) 2009 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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