期刊
PAIN
卷 138, 期 1, 页码 98-110出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2007.11.014
关键词
spinal cord; allodynia; hyperalgesia; neurotrophins; nociceptors; interneurons; GABA; neuropeptide Y; brain-derived neurotrophic factor; dorsal rhizotomy; sprouting
资金
- Canadian Institutes of Health Research (CIHR)
- International Spinal Research Trust
- MSFHR
- NSERC
Brain-derived neurotrophic factor (BDNF) has multiple effects on tropomyosin-related receptor kinase B - (TrkB) expressing neurons, including potentiation of spinal nociceptive transmission and stimulation of axon outgrowth. BDNF is upregulated in the spinal cord following dorsal root injury (DRI), a manipulation which elicits both pain and collateral sprouting. Transection of the C7 and C8 dorsal roots (C7/8 DRI) generates cold pain in the ipsilateral forepaw which peaks at 10 days, and resolves within three weeks after injury. In the present study, we investigated the influence of chronic BDNF sequestration, by intrathecal delivery of TrkB-Fc, on the plasticity of nociceptive circuitry and resultant cold pain behaviour following spinal deafferentation. C7/8 DRI resulted in a pronounced deafferentation of the C7 dorsal horn and significant depletion of both peptidergic- and non-peptidergic nociceptive projections. While changes in GAP-43 expression revealed that endogenous BDNF was exerting an overall plasticity-promoting influence on intraspinal axons after DRI, Continuous TrkB-Fc treatment stimulated sprouting of nociceptive terminals. DRI stimulated it BDNF-dependent increase in the density of GABAergic interneuronal processes, as indicated by increased vesicular GABA transporter - (VGAT) and neuropeptide Y - (NPY) positive terminal densities. Finally, chronic TrkB-Fc treatment prevented cold pain resolution. These findings demonstrate that endogenous BDNF has both plasticity-promoting and plasticity-suppressing effects on the intrinsic spinal components of nociceptive circuitry, which are likely to underlie cold pain behaviour following C7/8 DRI. (c) 2007 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据