期刊
TRAFFIC
卷 16, 期 3, 页码 298-309出版社
WILEY
DOI: 10.1111/tra.12247
关键词
high resolution microscopy; lipid droplet; myosin motor; nuclear envelope; organelle inheritance; peroxisome; yeast
类别
资金
- Canadian Institutes of Health Research [9208]
- Alberta Innovates [201201150] Funding Source: researchfish
Lipid droplets are ubiquitous cellular structures involved in energy homeostasis and metabolism that have long been considered as simple inert deposits of lipid. Here, we show that lipid droplets are bona fide organelles that are actively partitioned between mother cell and daughter cell in Saccharomyces cerevisiae. Video microscopy revealed that a subset of lipid droplets moves from mother cell to bud in an ordered, vectorial process, while the remaining lipid droplets are retained by the mother cell. Bud-directed movement of lipid droplets is mediated by the molecular motor Myo2p, while retention of lipid droplets occurs at the perinuclear endoplasmic reticulum. Lipid droplets are thus apportioned between mother cell and daughter cell at cell division rather than being made anew.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据