期刊
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
卷 28, 期 3, 页码 255-262出版社
WILEY-BLACKWELL
DOI: 10.1111/ppe.12114
关键词
Norwegian Mother and Child Cohort Study; early identification; Autism Birth Cohort Study; longitudinal studies; M-CHAT; autism spectrum disorders
资金
- Norwegian Ministry of Health and Care Services
- Norwegian Ministry of Education and Research
- Research Council of Norway/FUGE [151918]
- National Institute of Neurological Disorders and Stroke (NIH/NINDS), Bethesda, MD, USA [NS47537]
- National Institute of Environmental Health Sciences (NIH/NIEHS), Research Triangle Park, NC, USA [NO-ES-75558]
- National Institute of Neurological Disorders and Stroke, (NIH/NINDS), Bethesda, MD, USA [NS47537]
- Norwegian Research Council [196452]
Background Previous research on clinical and high-risk samples suggests that signs of autism spectrum disorder (ASD) can be detected between 1 and 2 years of age. We investigated signs of ASD at 18 months in a population-based sample and the association with later ASD diagnosis. Methods The study sample includes 52 026 children born 2003 through 2008 and is a subset of children that participated in the Norwegian Mother and Child Cohort (MoBa), a population-based longitudinal study, and the Autism Birth Cohort (ABC), a sub-study on ASD. Parents completed all 23 items from the Modified Checklist for Autism in Toddlers (M-CHAT) at 18 months. Results The M-CHAT 6-critical-item criterion and the 23-item criterion had a specificity of 97.9% and 92.7% and a sensitivity of 20.8% and 34.1%, respectively. In the 173 children diagnosed with ASD to date, 60 children (34.7%) scored above the cut-off on either of the screening criteria. The items with the highest likelihood ratios were 'interest in other children', 'show objects to others' and 'response to name'. Conclusion Even though one-third of the children who later received an ASD diagnosis were identified through M-CHAT items, the majority scored below cut-off on the screening criteria at 18 months. The results imply that it might not be possible to detect all children with ASD at this age.
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