期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2014, 期 -, 页码 1-4出版社
HINDAWI LTD
DOI: 10.1155/2014/208408
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资金
- National Natural Science Foundation of China [81072654/H3104]
- Shaanxi Innovative Research Team of Key Science and Technology [2012KCT-17]
Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serumR ANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.
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