期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/564961
关键词
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类别
资金
- AIRC
- Telethon [GGP09128, GGP11139B]
- Italian Ministry of Education, University and Research
- Italian Ministry of Health
- Polish National Science Centre [UMO-2011/01/M/NZ3/02128]
- BIO-IMAGing in research Innovation and Education [FP7-REGPOT-2010-1]
- Fondazione Italiana Sclerosi Multipla (FISM) [2010/B/1]
Reactive oxygen species (ROS) are a byproduct of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. An imbalance between ROS production and the cellular antioxidant defence system leads to oxidative stress. Environmental factors and genetic interactions play key roles in oxidative stress mediated pathologies. In this paper, we focus on cardiovascular diseases and obesity, disorders strongly related to each other; in which oxidative stress plays a fundamental role. We provide evidence of the key role played by p66(Shc) protein and protein kinase C (PKC) in these pathologies by their intracellular regulation of redox balance and oxidative stress levels. Additionally, we discuss possible therapeutic strategies aimed at attenuating the oxidative damage in these diseases.
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