期刊
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
卷 139, 期 4, 页码 495-505出版社
SAGE PUBLICATIONS LTD
DOI: 10.1016/j.otohns.2008.05.624
关键词
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资金
- Allergan
- Merz
- Elan
- Solstice
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- National Spasmodic Dysphonia Association
- Movement Disorder Society
- National Institute on Deafness and Other Communication Disorders
- AGENCY FOR HEALTHCARE RESEARCH AND QUALITY [R01HS018413] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [Z01NS002980, R01NS050425, ZIANS003031, R01NS058714, R01NS046340, R01NS041509] Funding Source: NIH RePORTER
OBJECTIVE: To identify research priorities to increase understanding of the pathogenesis, diagnosis, and improved treatment of spasmodic dysphonia. STUDY DESIGN AND SETTING: A multidisciplinary working group was formed that included both scientists and clinicians from multiple disciplines (otolaryngology, neurology, speech pathology, genetics, and neuroscience) to review currently available information on spasmodic dysphonia and to identify research priorities. RESULTS: Operational definitions for spasmodic dysphonia at different levels of certainty were recommended for diagnosis and recommendations made for a multicenter multidisciplinary validation study. CONCLUSIONS: The highest priority is to characterize the disorder and identify risk factors that may contribute to its onset. Future research should compare and contrast spasmodic dysphonia with other forms of focal dystonia. Development of animal models is recommended to explore hypotheses related to pathogenesis. Improved understanding of the pathophysiology of spasmodic dysphonia should provide the basis for developing new treatment options and exploratory clinical trials. SIGNIFICANCE: This document should foster future research to improve the care of patients with this chronic debilitating voice and speech disorder by otolaryngology, neurology, and speech pathology. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
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